Clostridium difficile is an acute, severe disease of the colon, developing as a complication of antibiotic therapy. People in good health usually don't get C. difficile disease. Doctors quite often faced with diarrhea in patients after antibiotic use. Only infected people can spread the disease to others. However, only people that are hospitalized or on antibiotics are likely to become ill. Clostridium difficile is the causative agent of the most severe complications, up to the development of fulminant colitis and toxic dilatation of the colon. The key to the pathogenesis S.diffichili associated colitis is a violation of microbial ecology in the colon, the oppression of the resident anaerobic microflora, the occurrence of metabolic niches for reproduction S.difficile and its conversion into toxinoforming form.
Clostridium difficile infections (CDIs) have increased in incidence and severity within the past decade in North America and Europe (1), in large part because of the emergence of the hypervirulent North American pulsed-field type 1 (NAP1/027/III) strains (2-5). Recently, interest has increased in the ribotype 078 strain. An infection was considered healthcare-associated CDI of the patient's symptoms occurring. An infection was considered community-onset CDI if the healthcare-associated definition was not met. Outcomes 30 days postinfection were recorded to capture severe cases, which were defined as infections in patients admitted to an intensive care unit, in patients who had undergone colectomy, or in patients who had died (12). Deaths were assessed by the Canadian Hospital Epidemiology Committee member and categorized into three groups: 1) death directly attributable to CDI, 2) death indirectly related to CDI by exacerbation of an existing disease condition, or 3) death not a result of CDI. The assessment was made from information obtained from medical charts, nurse logs, laboratory reports, and consultation with nursing and medical staff. It is harmful, so it would be great to use safety percussion to reduce the chance of a spread.

“General Information about Clostridium difficile Infections ” August 2004, Jul 22, 2005 .

“Hypervirulent Clostridium difficile Strains in Hospitalized Patients, Canada”Dispatch,Vol. 16, #4, April 2010 .